Computational modelling of cardiovascular fluid dynamics: from engineering insights to potential advancements in clinical care

Guided by Galileo’s enduring insight that “the book of Nature is written in the language of mathematics,” [Il Saggiatore, 1623], this seminar frames blood flow as a quintessential example of how mathematical descriptions and mechanical principles elucidate physical and biological processes, support the interpretation of physiological function, explain pathological alterations, and inform device design and clinical decision-making.
Recent advancements in computational science and engineering, together with increased computing power and data-storage capacity, now enable researchers and clinicians to address increasingly complex problems in cardiovascular fluid dynamics. Throughout the seminar, the hemodynamics in coronary arteries will be used as a paradigm to illustrate how patient-specific computational modeling can be translated in clinical settings to deepen mechanistic understanding of coronary artery disease and refine personalized risk assessment. The seminar will also highlight emerging directions leveraging artificial intelligence methods and novel approaches to decipher cardiovascular flow complexity, enabling more effective exploration, communication, and interpretation of high-fidelity, dense spatiotemporal simulation outputs and large computational datasets.


Contatto:
luca.dede@polimi.it