A global perspective on haemodynamics and other bodily fluids

Global haemodynamics emerge from the complex interaction of cardiac function, vascular properties, regulatory mechanisms, and interactions with other bodily fluids. While local flow features are essential for understanding site-specific pathology, a system-level perspective is crucial to capture the coupling between compartments and the propagation of haemodynamic disturbances throughout the cardiovascular system. In this presentation, we discuss recent advances in global haemodynamic modelling, using two representative application areas: cerebrospinal fluid (CSF) dynamics and systemic hypertension.

First, we illustrate how a geometric multiscale model of the cardiovascular system can be coupled with CSF dynamics to investigate intracranial pressure regulation and brain–spinal fluid interactions. This model highlights the role of global circulatory dynamics in shaping CSF flow patterns and pressure waves. Second, we consider hypertension as a paradigmatic example of the integrated action of all compartments of the cardiovascular system on the determination of systemic arterial pressure. Our results highlight a significant contribution of alterations in the venous system to the hypertensive state.

We conclude the presentation with a brief overview of current research, aiming at greater anatomical detail in the description of the cardiovascular system, as well as at the incorporation of its interactions with the respiratory system and regulatory mechanisms, with the mid-term objective of providing physiologically realistic computational models of orthostatic stress and real-life haemodynamics.

Contatto:
luca.dede@polimi.it