MOX Reports
The preprint collection of the Laboratory for Modeling and Scientific Computation MOX. It mainly contains works on numerical
analysis and mathematical modeling applied to engineering problems. MOX web site is mox.polimi.it
Found 1237 products
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04/2013 - 01/21/2013
Morlacchi, S.; Chiastra, C.; Cutrì, E.; Zunino, P.; Burzotta, F.; Formaggia, L.; Dubini, G.; Migliavacca, F.
Stent deformation, physical stress, and drug elution obtained with provisional stenting, conventional culotte and Tryton-based culotte to treat bifurcations: a virtual simulation study | Abstract | | Aims: To investigate the possible influence of different bifurcation stenting techniques on stent deformation, physical stress, and drug elution using an implemented virtual tool that comprehends structural, fluid dynamics and drug-eluting numerical models. Methods and results: A virtual bench test based on explicit dynamic modelling was used to simulate procedures
on bifurcated coronary vessels performed according to three different stenting techniques: provisional side branch stenting, culotte and Tryton-based culotte. Geometrical configurations obtained after stenting were used to perform fluid dynamics and drug elution analyses. Results show that major different pattern of mechanical deformation, shear stress and theoretical
drug elution are obtained using different techniques. Compared with conventional culotte, the dedicated Tryton seems to facilitate the intervention in terms of improved access to the main branch and lowers its biomechanical influence on the coronary bifurcation in terms of mechanical and hemodynamic parameters. However, since the Tryton stent is a bare metal stent, the drug elution obtained is lower. Conclusion: Numerical models might successfully complement the information on stenting procedures obtained
with traditional approaches as in vitro bench testing or clinical trials. Devices dedicated to bifurcations may facilitate procedure completion and may result in specific patterns of mechanical stress, regional blood flow and drug elution. |
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03/2013 - 01/20/2013
Antonietti, P.F.; Ayuso de Dios, B.; Bertoluzza, S.; Pennacchio, M.
Substructuring preconditioners for an $h-p$ Nitsche-type method | Abstract | | We propose and study an iterative substructuring method for an $h-p$ Nitsche-type discretization, following the original approach introduced in [Bramble, Pasciak, Schatz, Math. Comp., 1986] for conforming methods. We prove quasi-optimality with respect to the mesh size and the polynomial degree for the proposed preconditioner. Numerical experiments asses the performance of the preconditioner and verify the theory. |
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02/2013 - 01/11/2013
Brugiapaglia, S.; Gemignani, L.
On the simultaneous refinement of the zeros of H-palindromic polynomials | Abstract | | In this paper we propose a variation of the Ehrlich–Aberth method for the simultaneous refinement of the zeros of H-palindromic polynomials.
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01/2013 - 01/04/2013
Arnold, D.N.; Boffi, D.; Bonizzoni,F.
Tensor product finite element differential forms and their approximation properties | Abstract | | We discuss the tensor product construction for complexes of differential forms and show how it can be applied to define shape functions and degrees of freedom for finite element differential forms on cubes in n dimensions. These may be extended to curvilinear cubic elements, obtained as images of a reference cube under diffeomorphisms, by using the pullback transformation for differential forms to map the shape functions and degrees of freedom from the reference cube to the image finite element. This construction recovers and unifies several known finite element approximations in two and three dimensions. In this context, we study the approximation properties of the resulting finite element spaces in two particular cases: when the maps from the reference cube are affine, and when they are multilinear. In the former case the rate of convergence depends only on the degree of polynomials contained in the reference space of shape functions. In the latter case, the rate of approximation is degraded, with the loss more severe for differential forms of higher form degree. |
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56/2012 - 12/22/2012
Ieva, F.; Paganoni, A.M.
Risk Prediction for Myocardial Infarction via Generalized Functional Regression Models | Abstract | | In this paper, we propose a generalized functional linear regression model for a binary outcome indicating the presence/absence of a cardiac disease with a multivariate functional data among the relevant predictors. In particular
the motivating problem is an analysis of Electrocardiographic (ECG)traces of patients whose prehospital ECG has been sent to 118 Dispatch Center of Milan (the Italian free-toll number for emergencies) by life support personnel of the basic rescue units. The statistical analysis starts with a preprocessing step of ECGs, treated as multivariate functional data. They are reconstructed from noisy observations, then the biological variability is removed by a nonlinear registration procedure based on landmarks. Thus, a Multivariate Functional Principal Component Analysis (MFPCA) is carried
out on the variance-covariace matrix of the reconstructed and registered ECGs as well as of their first derivatives, in order to perform a data-driven dimensional reduction. The scores of the principal components that result to be significant are then used within a generalized functional regression model, together with other standard covariates of interest. Hence, a new
semi-automatic diagnostic procedure is proposed to model the probability of disease (in the case of interest, the probability of being affected by Left Bundle Brunch Block) and to classify patients. Finally, the performance of this classification method is evaluated through cross validation and compared with other methods proposed in literature. |
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55/2012 - 12/14/2012
Peng Chen, Alfio Quarteroni, Gianluigi Rozza
Uncertainty quantification of the human arterial network | Abstract | | This work aims at identifying and quantifying uncertainties from various sources in human cardiovascular system based on a one dimensional arterial network. A general analysis of different uncertainties and probability characterization with log-normal distribution of these uncertainties is introduced. Deriving from a deterministic one dimensional fluid structure interaction model, we establish the stochastic model as a coupled hyperbolic system incorporated with parametric uncertainties to describe the blood flow and pressure wave propagation in the arterial network. By applying a stochastic collocation method with sparse grid technique, we study systematically the statistics and sensitivity of the solution with respect to many different uncertainties in a relatively complete arterial network validated against clinical measurements for the first time. |
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54/2012 - 12/13/2012
Ettinger, B., Perotto, S.; Sangalli, L.M.
Spatial regression models over two-dimensional manifolds | Abstract | | We propose a regression model for data spatially distributed over nonplanar two-dimensional Riemannian manifolds. The model is a generalized
additive model with a roughness penalty term involving a suitable differential operator computed over the non-planar domain. Thanks to a
semi-parametric framework, the model allows for inclusion of space-varying covariate information. We show that the estimation problem can be solved
first by conformally mapping the non-planar domain to a planar domain and then by applying existing models for penalized spatial regression over planar domains, appropriately modified to account for the domain deformation. The flattening map and the estimation problem are both computed by resorting to a finite element approach. The estimators are linear in the observed data values and classical inferential tools are derived. The application driving this research is the study of hemodynamic forces on the wall of an internal carotid artery affected by an aneurysm. |
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53/2012 - 12/10/2012
Fumagalli, A.; Scotti, A.
An efficient XFEM approximation of Darcy flows in fractured porous media | Abstract | | Subsurface flows are strongly influenced by the presence of faults and large fractures that alter the permeability of the medium acting as barriers or conduits for the flow. An accurate description of the hydraulic properties of the fractures is thus essential for the modelling of oil migration or the exploitation of unconventional sources. However, the width of fractures is often small compared to the typical mesh size. To approximate the problem without refining the mesh to resolve the fracture we replace them with surfaces immersed in the porous matrix. Moreover we allow the surfaces to be non matching with the edges of the grid handling the discontinuities within elements with the XFEM approach. The method, originally developed for the single-phase Darcy problem is extended to the case of passive transport and multiphase flow. |
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