The "Seminario Matematico e Fisico di Milano" was officially inaugurated on 9 February 1927, following the constitution of its first Executive Council (27 November 1926).
The Seminar was established in collaboration between universities of Milan with the aim of spreading mathematical and physical knowledge and promoting studies and research in these fields.
The work of the Seminar consists of conferences, congresses, lectures and other activities addressed to its stated aims.

The "Seminar" has its official residence at the Department of Mathematics "Francesco Brioschi" of the Polytechnic School of Milan and runs its activities at the University of Milan, University of Milano-Bicocca and the Polytechnic School of Milan.