Direttore Vicario: Prof. Gabriele Grillo
Responsabile Gestionale: Dr.ssa Franca Di Censo
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• 2019 RISM Congress: Modelling the Cardiac Function - iHEART
Three days of lectures to focus on the latest achievements in modelling the heart function. For updated program and details for registration, please see http://iheart.polimi.it/mcf2019

### Prossimi Eventi

•  lug 02 mar 2019 Seminar Colette De Coster, A prescribed anisotropic mean curvature equation modeling the corneal shape: a paradigm of nonlinear analysis,  02-07-2019, ore 15:15

• Seminar
• Colette De Coster
• Univ. Valenciennes
• A prescribed anisotropic mean curvature equation modeling the corneal shape: a paradigm of nonlinear analysis
• Martedì 2 luglio 2019 alle ore 15:15
• Aula seminari 3° piano
• Abstract
In this talk, we survey some recent results concerning the Dirichlet problem for the prescribed anisotropic mean curvature equation
\begin{equation*}
{\rm -div}\left({\nabla u}/{\sqrt{1 + |\nabla u|^2}}\right) = -au + {b}/{\sqrt{1 + |\nabla u|^2}},
\end{equation*}
in a bounded Lipschitz domain $\Omega \subset \RR^N$, with $a,b>0$ parameters.
This equation appears in the description of the geometry of the human cornea, as well as in the modeling theory of capillarity phenomena for compressible fluids.

In this talk, we show how various techniques of nonlinear functional analysis can successfully be applied to derive a complete picture of the solvability patterns of the problem.
• Politecnico di Milano, Dipartimento di Matematica via Bonardi 9, 20133 Milano - Telefono: +39 02 2399 4505 - Fax: +39 02 2399 4568

•  lug 05 ven 2019 MOX Seminar Bianca Giovanardi, A scalable computational framework for large-scale simulation of fluid-driven fracture propagation,  05-07-2019, ore 14:00

• MOX Seminar
• Bianca Giovanardi
• MIT, Cambridge, MA, USA
• A scalable computational framework for large-scale simulation of fluid-driven fracture propagation
• Venerdì 5 luglio 2019 alle ore 14:00
• aula Saleri VI piano
• Abstract
Fluid-driven crack propagation concerns several areas of engineering, including structural, geotechnical, and petroleum engineering. The development of simulation tools for pressurized cracks propagating in realistic scenarios needs to tackle the complexity arising from the non-linear hydro-mechanical coupling of the fluid and the cracked solid in a suitable framework for large-scale applications.
In this talk, I will introduce the governing equations of hydraulic fracture and discuss well-known propagation regimes where the prob- lem can be treated analytically. I will then present a computational ap- proach to model the hydro-mechanical coupling of the fracturing solid and the fluid flow inside the propagating cracks. Benchmarks in 2D and 3D demonstrate the capability of the computational framework to successfully deal with a priori unknown and arbitrarily intricate crack paths, and with the need for large-scale simulations.
Time permitting, I will describe other recent efforts in developing advanced computational algorithms for large-scale simulation of complex material response, including elastic instabilities and material failure.

Contatto: edie.miglio@polimi.it
• Politecnico di Milano, Dipartimento di Matematica via Bonardi 9, 20133 Milano - Telefono: +39 02 2399 4505 - Fax: +39 02 2399 4568

•  lug 11 gio 2019 MOX Seminar Series Kent - Andre Mardal, Preconditioning of multiphysics problems with applications to the biomechanics of the brain,  11-07-2019, ore 14:00

• MOX Seminar Series
• Kent - Andre Mardal
• University of Oslo and Simula Research Laboratory
• Preconditioning of multiphysics problems with applications to the biomechanics of the brain
• Giovedì 11 luglio 2019 alle ore 14:00
• Aula consiglio VII piano, Edificio 14, Dipartimento di Matematica POLITECNICO DI MILANO
• Abstract
In this talk we will discuss preconditioning algorithms for monolithic schemes of coupled problems involving the coupling of porous and viscous flow as well as fluid-structure interaction and dimension reduction problems.
We explore how fractional Laplacian solvers may be utilized to obtain parameter robust schemes. The schemes are discussed in the context of biomechanical modelling of the waste clearance processes in the brain that is believed to fail in various forms of dementia such as Alzheimer's and Parkinson's diseases.

Contact: paolo.zunino@polimi.it

• Kent-Andre Mardal is a Professor at the University of Oslo and an adjuct researcher at Simula Research Laboratory. His research focus is on computational methods for life-science applications, where focus areas are robust multi-physics algorithms, high-performance preconditioning techniques, generic scientific software components, the microcirculation and metabolism of the brain, the cause of dementia such as Alzheimer’s disease and normal pressure hydrocephalus, and multi-dimensional coupling problems. Mardal has made core contributions to the FEniCS software library, the operator preconditioning technique, demonstrated transitional flow at low Reynolds number in blood flow and made crucial observations concerning the g-lymphatic system potentially involved in Alzheimer´s disease development.
• Politecnico di Milano, Dipartimento di Matematica via Bonardi 9, 20133 Milano - Telefono: +39 02 2399 4505 - Fax: +39 02 2399 4568

•  lug 18 gio 2019 Seminar Caterina La Porta, Complexity in biomedicine,  18-07-2019, ore 10:00

• Seminar
• Caterina La Porta
• Università degli Studi di Milano
• Complexity in biomedicine
• Giovedì 18 luglio 2019 alle ore 10:00
• Dipartimento di Matematica - 7° piano, Politecnico di Milano
• Abstract
In this talk, I will discuss our recent advances in understanding phenotypic plasticity of cancer cells using a combination of experiments, analysis of big data and computational models of complex regulatory networks. Next, I will discuss our results on protein aggregation in neurodegenerative pathologies, such as Alzheimer's and Huntington's disease.

In particular, I will report on the importance of protein clearance from the endoplasmic reticulum to drive protein aggregation and on our recent results on huntingtin heterogenous aggregation in which mutated forms of the protein are able to form oligomers with non-mutated forms.
• Politecnico di Milano, Dipartimento di Matematica via Bonardi 9, 20133 Milano - Telefono: +39 02 2399 4505 - Fax: +39 02 2399 4568

•  lug 22 lun 2019 lug 24 mer 2019 Convegno Rism 2019 - modelling the cardiac function - iheart 22/07/2019 - 24/07/2019

• CONVEGNO
• MCF2019
Rism 2019 - modelling the cardiac function - iheart
• organizzatori
A. Quarteroni, L. Dedè, A. Manzoni, S. Serra-Capizzano, C. Vergara, P. Zunino
• This congress, organised in the context of the prestigious Riemann International School of Mathematics, aims at focusing on the state of the art in the mathematical modelling and numerical simulation of the cardiac function and its clinical applications. This event will host 8 plenary lectures from distinguished scientists as well as contributed talks some presented by PhD students and some by senior researchers, and a poster session. PhD students selected for contributed presentation will be offered free accommodation. The Congress is organized by RISM and MOX - Politecnico di Milano, and is partially supported by the EU ERC-ADG - Advanced Grant iHEART Project ID: 740132 - iheart.polimi.it
• Lunedì 22 luglio 2019 - Mercoledì 24 luglio 2019
Villa Toeplitz - Varese
Politecnico di Milano, Dipartimento di Matematica via Bonardi 9, 20133 Milano - Telefono: +39 02 2399 4505 - Fax: +39 02 2399 4568