Tesi di LAUREA SPECIALISTICA Titolo Multiphysics/Multiscale Computational Modeling in Neuroelectronics Data 2009-12-23 Autore/i Brera, M Relatore Sacco, R. Relatore Jerome, J. Correlatore Mori, Y. Full text non disponibile Abstract The research activity of the present degree thesis can be cast within the context of Bio-Electronics, a fundamental subject in the wider area of Nanotechnologies. In particular, the focus is on devising a novel mathematical and computational model which can serve as a supporting tool for design in this innovative research area. The thesis is divided into the following chapters, devoted to: Chap.1: introducing the subject of bioelectronics and the basic concepts underlying the biological and electronic background, as well as realistic examples of bio-interfacing systems. Chap.2: discussing the mathematical models adopted to describe the coupling between a cell with an electronic substrate, as well as a hierarchy of models culminating in the Poisson-Nernst-Planck (PNP) and Multi-Scale (MS) formulations. Chap.3: describing the solution maps used to treat the nonlinear PNP and MS models and the resulting unified framework for their solution. Chap.4: discussing the appropriate numerical method for the discretization of the differential problem that must be solved within the functional iteration. Chap.5: validating the computational models discussed in the previous chapters of the thesis with numerical tests and actual simulations. Chap.6: drawing some conclusions and perspectives for future activities.