Codice 12/2008 Titolo A 3D/1D geometrical multiscale model of cerebral vasculature Data 2008-06-26 Autore/i Passerini, Tiziano; de Luca, Maria Rita; Formaggia, Luca; Quarteroni, Alfio; Veneziani, Alessandro Link Download full text Abstract Geometrical multiscale modeling is a strategy advocated in computational hemodynamics for representing in a single numerical model dynamics that involve different space scales. This approach is particularly useful to describe complex networks such as the circle of Willis in the cerebral vasculature. In this paper we present a multiscale model of the cerebral circulation where a one dimensional description of the circle of Willis, relying on the one-dimensional Euler equations, is coupled to a fully three dimensional model of a carotid artery, based on the solution of the incompressible Navier-Stokes equations. Even if vascular compliance is often not relevant to the meaningfulness of 3D results, it is crucial in the multiscale model, since it is the driving mechanism of pressure wave propagation. Unfortunately, 3D simulations in compliant domains still demand computational costs significantly higher than the rigid case. Appropriate matching conditions between the two models have been devised to concentrate the effects of the compliance at the interfaces and to obtain reliable results still solving a 3D problems on rigid vessels