Advances in numerical techniques and the ever increasing computational power have rendered the execution of forward models of total heart function feasible. Using such models based on clinical images and parameterized to reflect a given patient's physiology, are a highly promising approach to comprehensively and quantitatively characterize cardiovascular function in a given patient. Such models are anticipated to play a pivotal role in future precision medicine as a method to stratify diseases, optimize therapeutic procedures, predict outcomes and thus better inform clinical decision making.
However, to translate modeling into a clinically applicable modality a number of key challenges have to be addressed. In particular, expensive computational models must be made efficient enough to be compatible with clinical time frames. This can be addressed either with hierarchical models of varying complexity which are cheaper to evaluate, by using computational efficient techniques such as spatio-temporal adaptivity, or by exploiting the power of new HPC hardware through massive parallelization or the use of accelerators. Further, the etiology of most cardiac pathologies comprises Multiphysics aspects, requiring the coupling of various physics, which may be characterized by very different space and time scales, rendering their coupling a challenging endeavor. Finally and most importantly, to be of clinical utility generic models must be specialized based on clinical data, which requires complex parameterization and data assimilation procedures to match model behavior with clinical observations.
In this presentation, I will give an overview of our multi-physics forward modelling framework and our recent work on m personalising models using clinical data.
This seminar is organized within the ERC-2016-ADG Research project iHEART - An Integrated Heart Model for the simulation of the cardiac function, that has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 740132)